Eastland G W, Yang G, Thompson T
Methods Find Exp Clin Pharmacol. 1983 Sep;5(7):435-8.
The neutral, dimeric complexes of rhenium, bis (mu-carboxalato)-diaquotetrahalodirhenium (III) (carboxalato = acetato, propionato, or butyrato and halo = chloro or bromo), were synthesized and survival studies were done on mice bearing P-388 leukemia or B-16 melanoma. The complex bis (mu-propionato) diaquotetrabromodirhenium (III) proved to be the most effective in increasing the life span of the mice. The complex showed some activity against B-16, but virtually none against P-388. The complexes are all quite non-toxic.
合成了铼的中性二聚体配合物双（μ-羧基）-二水四卤代二铼（III）（羧基=乙酸根、丙酸根或丁酸根，卤=氯或溴），并对患有P-388白血病或B-16黑色素瘤的小鼠进行了存活研究。配合物双（μ-丙酸根）二水四溴代二铼（III）被证明在延长小鼠寿命方面最有效。该配合物对B-16显示出一定活性，但对P-388几乎没有活性。这些配合物都相当无毒。
