Berthoux F C, Genin C, Le Petit J C, Laurent B
Nephrologie. 1983;4(6):283-7.
Idiopathic mesangial IgA nephritis (Berger's disease) and Schönlein-Henoch purpura mesangial IgA nephritis (SHP) have a common immunopathological pattern. There is a weak association with the MHC class I antigen, B35, which is a poor prognosis marker in Berger's disease and which predisposes to renal involvement in SHP. There is also an association with the MHC class II antigen, DR4, whose signification remains unclear. Many familial cases of Berger's disease have been reported in patients bearing the HLA-B35 antigen. We proposed that Berger's disease and SHP should be viewed as a unique entity according to their common immunogenetics and also common immunopathology.
特发性系膜IgA肾病（伯杰氏病）和过敏性紫癜性系膜IgA肾病（SHP）具有共同的免疫病理模式。与MHC I类抗原B35存在弱关联，B35在伯杰氏病中是预后不良的标志物，且易导致SHP发生肾脏受累。还与MHC II类抗原DR4有关联，其意义尚不清楚。在携带HLA - B35抗原的患者中已报道了许多伯杰氏病的家族病例。我们提出，根据伯杰氏病和SHP共同的免疫遗传学及共同的免疫病理学，应将它们视为一个独特的实体。
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