IgA1和IgA2在循环免疫复合物以及伯杰氏和过敏性紫癜性肾小球肾炎的肾脏沉积物中的情况。
IgA1 and IgA2 in circulating immune complexes and in renal deposits of Berger's and Schönlein-Henoch glomerulonephritis.
作者信息
Coppo R, Basolo B, Mazzucco G, Bulzomì M R, Roccatello D, Messina M, Barbiano G, Martina G, Rollino C, Piccoli G
出版信息
Proc Eur Dial Transplant Assoc. 1983;19:648-54.
IgA subclasses in circulating immune complexes (IgA1IC), serum immunoglobulins and mesangial deposits in Berger's and Schönlein-Henoch glomerulonephritis (GN) were studied. Both IgA1IC and IgA2IC were significantly higher in Berger's and Schönlein-Henoch GN than in healthy people. In phases of clinical activity both IgAIC subclasses further increased. The IgA1/IgA2 ratio was found not to differ from controls in either groups of patients. An increase in polymeric IgA was observed in Berger's and in Schönlein-Henoch GN. Both IgA subclasses were found in mesangial deposits.
对伯杰氏病和过敏性紫癜性肾小球肾炎（GN）患者循环免疫复合物中的IgA亚类（IgA1IC）、血清免疫球蛋白和系膜沉积物进行了研究。伯杰氏病和过敏性紫癜性GN患者的IgA1IC和IgA2IC均显著高于健康人。在临床活动期，两种IgAIC亚类进一步升高。发现两组患者的IgA1/IgA2比值与对照组无差异。在伯杰氏病和过敏性紫癜性GN中均观察到聚合IgA增加。在系膜沉积物中发现了两种IgA亚类。
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