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猪肾对25-羟基胆钙化醇的体外代谢：低钙磷日粮水平的影响

The in vitro metabolism of 25-hydroxycholecalciferol by pig kidney: effect of low dietary levels of calcium and phosphorus.

作者信息

Sommerville B A, Fox J, Care A D, Swaminathan R

出版信息

Br J Nutr. 1978 Jul;40(1):159-62. doi: 10.1079/bjn19780107.

DOI:10.1079/bjn19780107
PMID:667000
Abstract
  1. Homogenates of pig kidney incubated in vitro convert 25-hydroxycholecalciferol to the dihydroxymetabolites almost as efficiently as homogenates of chick kidney under similar conditions. 2. The cortex of the kidney carries out this conversion more efficiently than does the medulla. 3. Kidneys from pigs given low calcium or low phosphorus diets produce about 40% more 1,25-dihydroxycholecalciferol than those from pigs given diets containing normal levels of Ca and P.
摘要
  1. 在体外孵育的猪肾匀浆将25-羟基胆钙化醇转化为二羟基代谢物的效率，几乎与在相似条件下的鸡肾匀浆一样高。2. 肾皮质进行这种转化的效率比髓质更高。3. 食用低钙或低磷饮食的猪的肾脏产生的1,25-二羟基胆钙化醇比食用钙和磷含量正常饮食的猪的肾脏多约40%。

相似文献

1
The in vitro metabolism of 25-hydroxycholecalciferol by pig kidney: effect of low dietary levels of calcium and phosphorus.猪肾对25-羟基胆钙化醇的体外代谢：低钙磷日粮水平的影响
Br J Nutr. 1978 Jul;40(1):159-62. doi: 10.1079/bjn19780107.
2
A comparison of the effects of dietary calcium and phosphorus deficiency on the in vitro and in vivo metabolism of 25-hydroxycholecalciferol in the chick.日粮钙和磷缺乏对雏鸡体内外25-羟胆钙化醇代谢影响的比较
Br J Nutr. 1978 Mar;39(2):411-4. doi: 10.1079/bjn19780053.
3
Metabolism in vitro of 25-hydroxycholecalciferol in chicks fed on phosphorus-deficient diets.以低磷日粮喂养的雏鸡体内25-羟胆钙化醇的体外代谢
Clin Sci Mol Med. 1978 Feb;54(2):197-200. doi: 10.1042/cs0540197.
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23, 25, 26-trihydroxycholecalciferol. A 25-hydroxycholecalciferol-26,23-lactone precursor.23,25,26-三羟基胆钙化醇。一种25-羟基胆钙化醇-26,23-内酯前体。
Biochem J. 1982 Jul 15;206(1):173-6. doi: 10.1042/bj2060173.
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Vitamin D metabolism and expression in rats fed on low-calcium and low-phosphorus diets.低钙低磷饮食喂养大鼠的维生素D代谢与表达
Biochem J. 1978 Feb 15;170(2):227-33. doi: 10.1042/bj1700227.
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Effect of oestrogen and 1,25-dihydroxycholecalciferol on 25-hydroxycholecalciferol metabolism in primary chick kidney-cell cultures.雌激素和1,25-二羟胆钙化醇对原代鸡肾细胞培养物中25-羟胆钙化醇代谢的影响。
Biochem J. 1978 Jul 15;174(1):231-6. doi: 10.1042/bj1740231.
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Vitamin D metabolism in adult rats at low and normal calcium intake and the effect of cadmium exposure.低钙和正常钙摄入成年大鼠的维生素D代谢及镉暴露的影响
Clin Sci Mol Med. 1977 Nov;53(5):439-46. doi: 10.1042/cs0530439.
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Effects of low phosphorus and low calcium diets on the production and metabolic clearance rates of 1,25-dihydroxycholecalciferol in pigs.低磷和低钙日粮对猪1,25-二羟胆钙化醇生成及代谢清除率的影响。
J Endocrinol. 1985 May;105(2):169-73. doi: 10.1677/joe.0.1050169.
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[Effect of 1 alpha-hydroxycholecalciferol on cellular calcium metabolism of kidney cortex (author's transl)].1α-羟胆钙化醇对肾皮质细胞钙代谢的影响（作者译）
Nihon Yakurigaku Zasshi. 1979 Jan;75(1):91-8.
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Regulation of metabolism of 25-hydroxycholecalciferol by kidney tissue in vitro by dietary calcium.膳食钙对肾组织体外25-羟基胆钙化醇代谢的调节作用。
Nat New Biol. 1972 May 10;237(71):63-4. doi: 10.1038/newbio237063a0.

引用本文的文献

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Phosphorus nutrition of growing pigs.生长猪的磷营养
Anim Nutr. 2022 Apr 2;9:127-137. doi: 10.1016/j.aninu.2022.01.010. eCollection 2022 Jun.
2
Localization of 25-hydroxyvitamin D3 1 alpha-hydroxylase and 24-hydroxylase along the rat nephron.25-羟维生素D3 1α-羟化酶和24-羟化酶在大鼠肾单位中的定位
Proc Natl Acad Sci U S A. 1981 Feb;78(2):1199-203. doi: 10.1073/pnas.78.2.1199.
3
Early changes in the adaptation to a low calcium diet in the chick.雏鸡对低钙饮食适应过程中的早期变化。
Calcif Tissue Int. 1983 May;35(3):339-43. doi: 10.1007/BF02405055.
4
Properties of guinea-pig kidney 25-hydroxyvitamin D3 1 alpha-hydroxylase assayed by isotope dilution-mass spectrometry.通过同位素稀释质谱法测定豚鼠肾脏25-羟基维生素D3 1α-羟化酶的特性。
Biochem J. 1988 Mar 1;250(2):521-6. doi: 10.1042/bj2500521.