23,25,26-三羟基胆钙化醇。一种25-羟基胆钙化醇-26,23-内酯前体。
23, 25, 26-trihydroxycholecalciferol. A 25-hydroxycholecalciferol-26,23-lactone precursor.
作者信息
Napoli J L, Horst R L
出版信息
Biochem J. 1982 Jul 15;206(1):173-6. doi: 10.1042/bj2060173.
Abstract
(23S)-23,25-Dihydroxycholecalciferol was converted into at least five metabolites in kidney homogenates prepared from 1,25-dihydroxycholecalciferol-treated chickens. One of these has been positively identified as 23,25,26-trihydroxycholecalciferol by u.v.-absorbance analysis, mass spectrometry and chemical formation of derivatives. 23,25,26-Trihydroxycholecaciferol produces 25-hydroxycholecalciferol-26,23-lactone when incubated in chick kidney homogenates.
摘要
在由1,25 - 二羟基胆钙化醇处理过的鸡所制备的肾脏匀浆中，(23S)-23,25 - 二羟基胆钙化醇被转化为至少五种代谢产物。其中一种已通过紫外吸收分析、质谱分析以及衍生物的化学合成被确认为23,25,26 - 三羟基胆钙化醇。23,25,26 - 三羟基胆钙化醇在鸡肾脏匀浆中孵育时会生成25 - 羟基胆钙化醇 - 26,23 - 内酯。
相似文献
1
23, 25, 26-trihydroxycholecalciferol. A 25-hydroxycholecalciferol-26,23-lactone precursor.23,25,26-三羟基胆钙化醇。一种25-羟基胆钙化醇-26,23-内酯前体。
Biochem J. 1982 Jul 15;206(1):173-6. doi: 10.1042/bj2060173.
2
25,26-Dihydroxycholecalciferol: a precursor in the renal synthesis of 25-hydroxycholecalciferol-26,23-lactone.25,26-二羟基胆钙化醇：25-羟基胆钙化醇-26,23-内酯肾合成过程中的一种前体。
Biochem Biophys Res Commun. 1980 Jul 31;95(2):520-8. doi: 10.1016/0006-291x(80)90815-3.
3
4
(23S)-1,23,25-Trihydroxycholecalciferol, an intestinal metabolite of 1,25-dihydroxycholecalciferol.（23S）-1,23,25-三羟基胆钙化醇，1,25-二羟基胆钙化醇的一种肠道代谢产物。
Biochem J. 1983 Jul 15;214(1):261-4. doi: 10.1042/bj2140261.
5
23,25-Dihydroxyvitamin D3: a natural precursor in the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone.23,25-二羟基维生素D3：25-羟基维生素D3-26,23-内酯生物合成中的天然前体。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4805-8. doi: 10.1073/pnas.78.8.4805.
6
Role of kidney tissue in the production of 25-hydroxyvitamin D3-26,23-lactone and 1 alpha, 25-dihydroxyvitamin D3-26,23-lactone.肾组织在25-羟基维生素D3-26,23-内酯和1α,25-二羟基维生素D3-26,23-内酯生成中的作用。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6411-4. doi: 10.1073/pnas.77.11.6411.
7
Isolation and identificaton of 25-hydroxy-24-oxocholecalciferol: a metabolite of 25-hydroxycholecalciferol.25-羟基-24-氧代胆钙化醇的分离与鉴定：一种25-羟基胆钙化醇的代谢产物。
Biochem Biophys Res Commun. 1980 Jul 16;95(1):177-81. doi: 10.1016/0006-291x(80)90720-2.
8
Effect of oestrogen and 1,25-dihydroxycholecalciferol on 25-hydroxycholecalciferol metabolism in primary chick kidney-cell cultures.雌激素和1,25-二羟胆钙化醇对原代鸡肾细胞培养物中25-羟胆钙化醇代谢的影响。
Biochem J. 1978 Jul 15;174(1):231-6. doi: 10.1042/bj1740231.
9
The in vitro metabolism of 25-hydroxycholecalciferol by pig kidney: effect of low dietary levels of calcium and phosphorus.猪肾对25-羟基胆钙化醇的体外代谢：低钙磷日粮水平的影响
Br J Nutr. 1978 Jul;40(1):159-62. doi: 10.1079/bjn19780107.
10
Biological activity of 24,24-difluoro-25-hydroxycholecalciferol in chicks.24,24-二氟-25-羟基胆钙化醇在雏鸡中的生物活性
J Nutr. 1983 Aug;113(8):1607-12. doi: 10.1093/jn/113.8.1607.
引用本文的文献
1
A new insight into the role of rat cytochrome P450 24A1 in metabolism of selective analogs of 1α,25-dihydroxyvitamin D₃.大鼠细胞色素 P450 24A1 在 1α,25-二羟维生素 D₃ 选择性类似物代谢中的作用的新见解。
Arch Biochem Biophys. 2011 May 1;509(1):33-43. doi: 10.1016/j.abb.2011.02.004. Epub 2011 Feb 19.
2
(23S)-1,23,25-Trihydroxycholecalciferol, an intestinal metabolite of 1,25-dihydroxycholecalciferol.（23S）-1,23,25-三羟基胆钙化醇，1,25-二羟基胆钙化醇的一种肠道代谢产物。
Biochem J. 1983 Jul 15;214(1):261-4. doi: 10.1042/bj2140261.
本文引用的文献
1
Metabolic pathway to 25-hydroxyvitamin D3-26,23-lactone from 25-hydroxyvitamin D3.从25-羟基维生素D3生成25-羟基维生素D3-26,23-内酯的代谢途径。
FEBS Lett. 1982 Feb 8;138(1):83-7. doi: 10.1016/0014-5793(82)80400-6.
2
23,25-Dihydroxyvitamin D3: a natural precursor in the biosynthesis of 25-hydroxyvitamin D3-26,23-lactone.23,25-二羟基维生素D3：25-羟基维生素D3-26,23-内酯生物合成中的天然前体。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):4805-8. doi: 10.1073/pnas.78.8.4805.
3
Stereochemistry of 25-hydroxyvitamin D3-26,23-lactone and 1 alpha, 25-dihydroxyvitamin D3-26,23-lactone in rat serum.大鼠血清中25-羟基维生素D3-26,23-内酯和1α,25-二羟基维生素D3-26,23-内酯的立体化学
FEBS Lett. 1981 Nov 16;134(2):207-11. doi: 10.1016/0014-5793(81)80603-5.
4
25,26-dihydroxyvitamin D3 is not a major intermediate in 25-hydroxyvitamin D3-26,23-lactone formation.25,26 - 二羟基维生素D3不是25 - 羟基维生素D3 - 26,23 - 内酯形成过程中的主要中间体。
Arch Biochem Biophys. 1981 Dec;212(2):754-8. doi: 10.1016/0003-9861(81)90419-7.
5
25-OHD3-26,23 lactone: demonstration of kidney-dependent synthesis in the pig and rat.
Biochem Biophys Res Commun. 1980 Mar 13;93(1):149-54. doi: 10.1016/s0006-291x(80)80258-0.
6
Competitive protein-binding radioassay of 24,25-dihydroxyvitamin D in sera from normal and anephric subjects.正常人和无肾受试者血清中24,25-二羟维生素D的竞争性蛋白结合放射测定法
Arch Biochem Biophys. 1977 Aug;182(2):390-5. doi: 10.1016/0003-9861(77)90519-7.
7
25-OHD3-26,23-lactone: a metabolite of vitamin D3 that is 5 times more potent than 25-OHD3 in the rat plasma competitive protein binding radioassay.25-羟基维生素D3-26,23-内酯：维生素D3的一种代谢产物，在大鼠血浆竞争性蛋白结合放射测定中，其效力比25-羟基维生素D3高5倍。
Biochem Biophys Res Commun. 1979 Jul 12;89(1):286-93. doi: 10.1016/0006-291x(79)90976-8.
8
25-Hydroxyvitamin D3 26,23-lactone: a new in vivo metabolite of vitamin D.
Biochemistry. 1979 Oct 30;18(22):4775-80. doi: 10.1021/bi00589a002.
Zotero 插件