Takahashi Y, Hirata Y
Tohoku J Exp Med. 1983 Dec;141(4):463-71. doi: 10.1620/tjem.141.463.
Twenty-one patients with painful diabetic neuropathy were followed up for about 18 months by means of physical and psychological tests. Patients with painful diabetic neuropathy had significantly more neurotic, anxious and depressive traits than those with non-painful diabetic neuropathy. During the course of the study, 17 patients out of 21 were found to be relieved of their neuropathic symptoms with improved blood glucose control and medications. However, despite this improvement, diabetic retinopathy and nephropathy of the patients deteriorated. Patients with improved neuropathy had gained body weight, with a concomitant relief of depression, nervous tendency and anxiety. However, lack of extroversion was not changed at all. Patients with painful diabetic neuropathy were significantly less extroversive than those with non-painful diabetic neuropathy, even when their neuropathic symptoms might have improved. This study shows that although nervousness, anxiety and depressive tendencies may be secondary to the symptoms of painful diabetic neuropathy, lack of extroversion can be a primary characteristic trait which may easily induce painful diabetic neuropathy.
通过身体和心理测试对21例疼痛性糖尿病神经病变患者进行了约18个月的随访。与非疼痛性糖尿病神经病变患者相比，疼痛性糖尿病神经病变患者具有明显更多的神经质、焦虑和抑郁特质。在研究过程中，21例患者中有17例通过改善血糖控制和药物治疗缓解了神经病变症状。然而，尽管有这种改善，患者的糖尿病视网膜病变和肾病仍恶化了。神经病变改善的患者体重增加，同时抑郁、神经质倾向和焦虑得到缓解。然而，外向性缺乏完全没有改变。即使疼痛性糖尿病神经病变患者的神经病变症状可能有所改善，他们的外向性也明显低于非疼痛性糖尿病神经病变患者。这项研究表明，虽然紧张、焦虑和抑郁倾向可能是疼痛性糖尿病神经病变症状的继发表现，但外向性缺乏可能是一种主要特征性特质，容易诱发疼痛性糖尿病神经病变。
