Tavakoli Mitra, Malik Rayaz A
University of Manchester and Manchester Royal Infirmary, Division of Cardiovascular Medicine, Manchester, UK.
Expert Opin Pharmacother. 2008 Dec;9(17):2969-78. doi: 10.1517/14656560802498149.
The commonest cause of peripheral neuropathy is diabetes and pain occurs in approximately 30% of diabetic patients with neuropathy. It is extremely distressing for the patient and poses significant difficulties in management, as no treatment to date provides total relief and the side effects of therapy limit dose titration. Understanding the pathogenesis of diabetic neuropathy may lead to the development of new treatments for preventing nerve damage. Furthermore, a better understanding of the mechanisms that modulate pain may lead to more effective relief of painful symptoms. This review provides an update on the assessment and treatment of painful diabetic neuropathy.
周围神经病变最常见的病因是糖尿病，约30%的糖尿病神经病变患者会出现疼痛。这给患者带来极大痛苦，也给治疗带来重大困难，因为迄今为止尚无治疗方法能完全缓解疼痛，且治疗的副作用限制了剂量滴定。了解糖尿病神经病变的发病机制可能会带来预防神经损伤的新治疗方法。此外，更好地理解调节疼痛的机制可能会更有效地缓解疼痛症状。本综述提供了关于疼痛性糖尿病神经病变评估和治疗的最新情况。
