Onyemelukwe G C, Isah H S, Mba E C, Awunnor-Renner C, Mohammed I
Trop Geogr Med. 1983 Dec;35(4):347-51.
Glycosylated haemoglobin (HbA1) was determined by a microcolumn technique using Biorex 70 resin in normal Nigerians and in patients with diabetes, iron deficiency anaemia, sickle cell disease and renal failure. Mean %HbA1 was 10.0 +/- 1.9% in controls which is higher than levels reported in Caucasians. HbAS but not HbSS had a reducing effect on the %HbA1 which was also found elevated in iron deficiency anaemia and diabetes mellitus. Factors peculiar to tropical medical practice affecting glycosylated haemoglobin must be appreciated and further investigated to assess the usefulness of HbA1 determination in the long term control of diabetes mellitus.
采用微柱技术，使用Biorex 70树脂，对正常尼日利亚人和患有糖尿病、缺铁性贫血、镰状细胞病及肾衰竭的患者测定糖化血红蛋白（HbA1）。对照组的平均HbA1百分比为10.0±1.9%，高于高加索人报道的水平。HbAS而非HbSS对HbA1百分比有降低作用，缺铁性贫血和糖尿病患者的HbA1百分比也升高。必须认识到热带医学实践中影响糖化血红蛋白的特殊因素，并进一步研究，以评估HbA1测定在糖尿病长期控制中的有用性。
