Zaslavsky B Y, Ossipov N N, Rogozhin S V
Biochim Biophys Acta. 1978 Jun 16;510(1):151-9.
The hemolytic action of a number of homologous series of cationic surfactants on human erythrocytes was measured. The hemolytic effects of anionic, nonionic and cationic surface-active agents are compared. The relationship which exists between the key physicochemical properties of surfactants (critical micelle concentration, hydrophile-lipophile balance) and their hemolytic capacities is discussed. The parameters required to compare the actions of various surfactants on different cellular membranes are considered in relation to the study of the correlation between the surfactant lytic effects and the features of the membrane molecular organization.
测定了一系列同系阳离子表面活性剂对人红细胞的溶血作用。比较了阴离子、非离子和阳离子表面活性剂的溶血效果。讨论了表面活性剂的关键物理化学性质(临界胶束浓度、亲水亲油平衡)与其溶血能力之间的关系。在研究表面活性剂裂解作用与膜分子组织特征之间的相关性时,考虑了比较各种表面活性剂对不同细胞膜作用所需的参数。