[红细胞表面化学修饰对其抵抗烷基硫酸钠溶血作用稳定性的影响]
[Effect of chemical modification of the surface of erythrocytes on their stability to the hemolytic action of sodium alkyl sulfates].
作者信息
Osipov N N, Zaslavskiĭ B Iu, Rogozhin S V
出版信息
Biokhimiia. 1978 Sep;43(9):1704-9.
The hemolytic action of a homologous series of sodium alkyl sulfates (C8 to C15) on dog and human erythrocytes was measured. The influence of trypsin, pronase and neuraminidase treatments on the lytic resistance of human red cells was studied. A new approach evaluating the hemolytic activity of ionic surfactants is expressed as a ratio of a concentration providing 50% lysis to its CMC-value. The results obtained are examined for their bearing on the use of surfactants as a means to study the structure organization of biological membranes.
测定了一系列烷基硫酸钠（C8至C15）对狗和人红细胞的溶血作用。研究了胰蛋白酶、链霉蛋白酶和神经氨酸酶处理对人红细胞抗溶能力的影响。一种评估离子表面活性剂溶血活性的新方法表示为产生50%溶血的浓度与其临界胶束浓度值的比值。研究所得结果对于表面活性剂作为研究生物膜结构组织手段的应用意义进行了考察。
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