Stufano N, Altomare E, Conese A, Sabbà C, Carbone P, Vendemiale G, Palasciano G, Albano O
Boll Soc Ital Biol Sper. 1983 Dec 30;59(12):1849-54.
Large amounts of intraerythrocyte 2-3 diphosphoglycerate (2-3 DPG) increase red cell oxygen-releasing capacity. Since glycosylated hemoglobins, found in higher percentages in diabetics, have an increased oxygen affinity, 2-3 DPG concentration was assayed in 12 diabetics (4 I.D.D., 8 N.I.D.D.) and 18 healthy volunteers. 2-3 DPG was related to glycemic fasting values and to glycosylated hemoglobins to evaluate if 2-3 DPG levels increase in diabetics as a compensatory mechanism to prevent peripheral hypoxia. 2-3 DPG values were significantly higher in diabetics than in normals: 11.4 mumol/gHb +/- 1.7 (= M +/- 1 SD) vs 9.8 mumol/gHb +/- 2.3 (p less than 0.05). 2-3 DPG did not correlate significantly to glycosylated hemoglobins or to glycemic values neither in diabetics nor in normals. These preliminary observations emphasize the usefullness of 2-3 DPG assay in evaluating peripheral oxygenation in diabetics: 2-3 DPG is higher in diabetics but does not correlate to glycemic equilibrium.
大量红细胞内2,3 - 二磷酸甘油酸（2,3 - DPG）可提高红细胞的氧释放能力。由于糖尿病患者体内糖化血红蛋白的比例较高，且其氧亲和力增加，因此对12名糖尿病患者（4名胰岛素依赖型糖尿病患者，8名非胰岛素依赖型糖尿病患者）和18名健康志愿者的2,3 - DPG浓度进行了测定。将2,3 - DPG与空腹血糖值及糖化血红蛋白相关联，以评估糖尿病患者的2,3 - DPG水平是否升高，作为预防外周组织缺氧的一种代偿机制。糖尿病患者的2,3 - DPG值显著高于正常人：分别为11.4 μmol/gHb ± 1.7（=平均值±标准差）和9.8 μmol/gHb ± 2.3（p < 0.05）。无论是糖尿病患者还是正常人，2,3 - DPG与糖化血红蛋白或血糖值均无显著相关性。这些初步观察结果强调了2,3 - DPG检测在评估糖尿病患者外周氧合方面的有用性：糖尿病患者的2,3 - DPG水平较高，但与血糖平衡无关。
