Neu H C
Diagn Microbiol Infect Dis. 1983 Mar;1(1):41-7. doi: 10.1016/0732-8893(83)90031-7.
Too little attention has been given to the correlation of antimicrobial susceptibility tests and the pharmacokinetics of antimicrobial agents. Ability to perform and provide reproducible, rapid, minimal inhibitory concentration data, combined with the knowledge of serum levels, can be used to yield inhibitory quotients which will improve the chemotherapy of serious infections. Antimicrobial susceptibilities have to be provided rapidly for the life-threatening infections that occur in certain clinical settings. Antimicrobial susceptibilities also must be provided in a manner that demonstrates that one may not be able to achieve therapeutic concentrations with certain drugs. We have reached an era in which knowledge of an organism being susceptible or resistant is no longer adequate.
对抗菌药物敏感性试验与抗菌药物药代动力学之间的相关性关注过少。能够进行并提供可重复、快速的最低抑菌浓度数据，再结合血清水平的知识，可用于得出抑制商数，这将改善严重感染的化疗效果。对于某些临床环境中出现的危及生命的感染，必须迅速提供抗菌药物敏感性结果。抗菌药物敏感性结果还必须以一种方式呈现，以表明使用某些药物可能无法达到治疗浓度。我们已经进入了一个仅了解生物体是敏感还是耐药已不再足够的时代。
