尼日利亚菌素对兔晶状体中钠、钾和钙离子分布的影响。

Effect of nigericin on distribution of sodium, potassium and calcium ion in rabbit lens.

作者信息

Horiuchi M, Iwata S

出版信息

Exp Eye Res. 1983 Nov;37(5):439-45. doi: 10.1016/0014-4835(83)90019-2.

Abstract

Nigericin, a carboxylic monovalent cation ionophore, induced opacification in the rabbit lens within 2 hr of incubation at 37 degrees C at a concentration of 10(-7)M. The opacification was in the subcapsular region where a marked degree of Ca2+ accumulation and change in the monovalent cation balance occurred. Nigericin may accumulate and act locally at the surface region of the lens, presumably due to the high lipid solubility of nigericin. Nigericin induced an opacification of the lens when applied either to the anterior chamber or to the vitreous of rabbit eye.

摘要

尼日利亚菌素是一种羧酸单价阳离子离子载体，在37℃下以10^(-7)M的浓度孵育2小时内，可诱导兔晶状体浑浊。浑浊发生在囊下区域，该区域出现了显著程度的Ca2+积累和单价阳离子平衡变化。尼日利亚菌素可能会在晶状体表面区域积累并局部起作用，推测是由于尼日利亚菌素具有高脂质溶解性。当将尼日利亚菌素应用于兔眼前房或玻璃体时，均可诱导晶状体浑浊。