Hashimoto H, Nakajima T, Nishimura T, Kudo Y, Takeda Y, Nakao M, Kanaya H, Horiguchi Y
Folia Psychiatr Neurol Jpn. 1983;37(2):137-44. doi: 10.1111/j.1440-1819.1983.tb00313.x.
The effect of D-phenylalanine on the concentrations of brain catecholamines, serotonin, beta-phenylethylamine and amino acids was examined using rats injected intraperitoneally with 200 mg/kg of D-phenylalanine. The contents of these monoamines in the rat brain were not affected by the administration of D-phenylalanine. No spectacular change was observed in the concentrations of brain amino acids except phenylalanine, which increased about four times during 30-60 minutes after the injection. This increase was attributed to the administered D-phenylalanine. To confirm the finding that D-phenylalanine did not affect the content of beta-phenylethylamine, the metabolism of D-phenylalanine was examined using D-[14C]-phenylalanine. It was proven that D-phenylalanine did not convert to beta-phenylethylamine. On the basis of these findings the antidepressant effect of D-phenylalanine was critically discussed.
使用腹腔注射200mg/kg D-苯丙氨酸的大鼠，研究了D-苯丙氨酸对脑内儿茶酚胺、5-羟色胺、β-苯乙胺和氨基酸浓度的影响。给予D-苯丙氨酸并未影响大鼠脑内这些单胺的含量。除苯丙氨酸外，脑内氨基酸浓度未观察到显著变化，注射后30 - 60分钟内苯丙氨酸浓度增加了约四倍。这种增加归因于给予的D-苯丙氨酸。为证实D-苯丙氨酸不影响β-苯乙胺含量这一发现，使用D-[14C]-苯丙氨酸研究了D-苯丙氨酸的代谢。结果证明D-苯丙氨酸不会转化为β-苯乙胺。基于这些发现，对D-苯丙氨酸的抗抑郁作用进行了批判性讨论。
