Fitzpatrick D W, Boyd K E, Watts B M
Department of Foods and Nutrition, University of Manitoba, Winnipeg, Canada.
Toxicol Lett. 1988 Mar;40(3):241-5. doi: 10.1016/0378-4274(88)90047-1.
Male Sprague-Dawley rats (180 g) were orally dosed with deoxynivalenol (DON) and T-2 toxin at 2.5 mg kg-1 body weight. Brains were collected 24 h postdosing, dissected into five brain regions and analyzed for biogenic monoamines by high performance liquid chromatography with electrochemical detection. DON and T-2 toxin treatment resulted in significantly elevated concentrations of the indoleamines, serotonin (HT) and 5-hydroxy-3-indoleacetic acid (HIAA) in all brain regions examined, whereas norepinephrine (NE) and dopamine (DA) regional concentrations were not significantly altered. These results indicate that DON and T-2 toxin influence brain biogenic monamine metabolism, and suggest that the central nervous system (CNS) actions of these trichothecenes are similar.
雄性斯普拉格-道利大鼠（180克）经口给予脱氧雪腐镰刀菌烯醇（DON）和T-2毒素，剂量为2.5毫克/千克体重。给药后24小时收集大脑，将其解剖为五个脑区，并通过高效液相色谱-电化学检测法分析生物胺。DON和T-2毒素处理导致在所检查的所有脑区中吲哚胺、5-羟色胺（5-HT）和5-羟基-3-吲哚乙酸（5-HIAA）的浓度显著升高，而去甲肾上腺素（NE）和多巴胺（DA）的区域浓度没有显著变化。这些结果表明，DON和T-2毒素影响大脑生物胺代谢，并提示这些单端孢霉烯族毒素的中枢神经系统（CNS）作用相似。
