Salmon R B, Saidel G M, Primiano F P, Niewoehner D E, Chester E H
J Biomech. 1983;16(12):993-1002. doi: 10.1016/0021-9290(83)90100-8.
The effects of regional lung differences in alveolar mechanics on the transpulmonary pressure-volume (Ptp-V) relationship and the single-breath washout (SBW) of nitrogen were investigated by mathematical modeling and postmorten human lung experiments. Regional nonuniformity in alveolar collapse and re-opening were associated with differences in gravitational stress or elasticity. Model simulations predict that neither type of regional nonuniformity qualitatively affects the shape of the Ptp-V curve, but does affect the terminal (or small-volume) portion of the SBW. Comparisons of characteristics of the Ptp-V and SBW curves indicate that regional nonuniformity in alveolar collapse is an important mechanism associated with ventilation inhomogeneity.
通过数学建模和人体肺脏尸检实验，研究了肺泡力学中区域肺差异对跨肺压力-容积（Ptp-V）关系及氮气单次呼吸冲洗（SBW）的影响。肺泡塌陷和重新开放的区域不均匀性与重力应力或弹性差异有关。模型模拟预测，这两种区域不均匀性类型均不会定性地影响Ptp-V曲线的形状，但会影响SBW的终末（或小容积）部分。Ptp-V曲线和SBW曲线特征的比较表明，肺泡塌陷的区域不均匀性是与通气不均匀性相关的重要机制。
