甲状腺部分切除术后甲状腺功能正常的甲状腺肿患者垂体-甲状腺轴的研究。

Study of the pituitary-thyroid axis in euthyroid goiter after partial thyroidectomy.

作者信息

Lombardi G, Panza N, Lupoli G, Leonello D, Carlino M, Minozzi M

出版信息

J Endocrinol Invest. 1983 Dec;6(6):485-7. doi: 10.1007/BF03348349.

PMID:6672072

Abstract

The aim of this study was to investigate the time involved after hemithyroidectomy in reaching a new steady state in thyroid function and the relationship between thyroid hormones, basal TSH levels and TSH response to TRH. The investigations were performed on 35 patients 12-18 months after partial thyroidectomy in the first investigation and after 24-30 months in the second investigation. Tests included T4, T3, FT4, FT3 serum levels, basal serum TSH and TSH response to TRH. None of the patients received thyroid replacement and 38 healthy subjects of comparable age and sex were used as controls. We conclude that: i) the time involved in reaching a new steady state of thyroid function in hemithyroidectomized patients is variable and may take a long time; ii) TSH response to TRH returns to the normal range later than thyroid hormone and basal TSH levels.

摘要

本研究的目的是调查甲状腺半切除术后达到甲状腺功能新稳态所需的时间，以及甲状腺激素、基础促甲状腺激素（TSH）水平与TSH对促甲状腺激素释放激素（TRH）反应之间的关系。首次调查在35例患者甲状腺部分切除术后12 - 18个月进行，第二次调查在术后24 - 30个月进行。检测项目包括血清总甲状腺素（T4）、总三碘甲状腺原氨酸（T3）、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）水平、基础血清TSH以及TSH对TRH的反应。所有患者均未接受甲状腺替代治疗，并选取38名年龄和性别匹配的健康受试者作为对照。我们得出以下结论：i）甲状腺半切除患者达到甲状腺功能新稳态所需的时间因人而异，可能需要很长时间；ii）TSH对TRH的反应恢复到正常范围的时间比甲状腺激素和基础TSH水平晚。