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[妊娠、糖尿病与胰岛素泵。预后会更好吗?]

[Pregnancy, diabetes and the insulin pump. A better prognosis?].

作者信息

Fenichel P, Verdino P, Melandri E, Boutte P, Harter M, Gillet J Y

出版信息

J Gynecol Obstet Biol Reprod (Paris). 1983;12(8):883-9.

PMID:6672082
Abstract

The fetal prognosis in pregnancy in a diabetic woman depends mainly on the blood sugar equilibrium of the mother that can be obtained, since the normal range lessens the chances of fetal abnormalities. This has been demonstrated in this series, since a system that uses the continuous automatic administration of insulin has been used. Six diabetic women were treated with continuous subcutaneous perfusion of insulin in the second half of pregnancy. The quality of the maternal blood sugar equilibrium has been proved by the normal values of glycosylated haemoglobin and the values of venous blood sugar which were always within the mean of the normal range. The tolerance of the technique is excellent (83 days in mean without a single complication). In 4 out of the 6 cases the baby was born at the 38th week of pregnancy and studies show that there was no increase in weight and a very low level of neonatal hypoglycaemia. It seems desirable to use this kind of insulin therapy which should help to contribute to a better fetal prognosis in diabetic pregnancies.

摘要

糖尿病女性孕期的胎儿预后主要取决于能够实现的母亲血糖平衡,因为正常范围可降低胎儿出现异常的几率。本系列研究已证实了这一点,因为采用了持续自动注射胰岛素的系统。6名糖尿病女性在妊娠后半期接受了胰岛素皮下持续灌注治疗。糖化血红蛋白的正常数值以及静脉血糖值始终处于正常范围均值内,证明了母亲血糖平衡的质量。该技术耐受性极佳(平均83天无任何并发症)。6例中有4例婴儿在妊娠第38周出生,研究表明其体重未增加且新生儿低血糖水平极低。使用这种胰岛素疗法似乎是可取的,它应有助于改善糖尿病孕妇的胎儿预后。

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