高钾血症对犬血清及心肌地高辛浓度影响的研究。

Studies on the effects of hyperkalemia on serum and myocardial digoxin concentration in dogs.

作者信息

Kori Y, Fujitani K, Nagai I

出版信息

Jpn Heart J. 1983 Nov;24(6):947-59. doi: 10.1536/ihj.24.947.

DOI:10.1536/ihj.24.947

Abstract

The effects of hyperkalemia on serum and myocardial digoxin (DX) concentration was studied in conjunction with hemodynamic changes in 31 normal dogs. The myocardial DX concentration in the hyperkalemic (HK) group was significantly lower than that in normokalemic (NK) group, despite a significantly higher serum DX concentration in the HK group. In the HK group, the myocardial sodium concentration was significantly lower than in the NK group. Coincident with these biochemical changes, no increase of LV max dP/dt after DX administration was observed in the HK group. These results suggest that there might be competitive antagonism between myocardial uptake of potassium and DX.

摘要

结合31只正常犬的血流动力学变化，研究了高钾血症对血清和心肌地高辛（DX）浓度的影响。高钾血症（HK）组的心肌DX浓度显著低于正常血钾（NK）组，尽管HK组的血清DX浓度显著更高。在HK组中，心肌钠浓度显著低于NK组。与这些生化变化一致，HK组在给予DX后未观察到左心室最大dP/dt增加。这些结果表明，心肌对钾和DX的摄取之间可能存在竞争性拮抗作用。