胍基乙磺酸盐和牛磺酸在大鼠视网膜中转运的体外研究。
In vitro studies of guanidinoethyl sulfonate and taurine transport in the rat retina.
作者信息
Lake N, Cocker S E
出版信息
Neurochem Res. 1983 Dec;8(12):1557-63. doi: 10.1007/BF00964157.
PMID:6672640
Abstract
The present study reports inhibition of taurine uptake in the rat retina in vitro to 49% of control by 1 mM guanidinoethyl sulfonate. No efflux of preloaded [14C]taurine was observed by incubation in the presence of guanidinoethyl sulfonate. The in vivo depletion of retinal taurine by guanidinoethyl sulfonate treatment may arise owing to antagonism of taurine transport into the retina from the blood.
摘要
本研究报告称，在体外实验中，1 mM 胍基乙磺酸盐可将大鼠视网膜中牛磺酸的摄取抑制至对照水平的49%。在胍基乙磺酸盐存在的情况下进行孵育，未观察到预加载的[14C]牛磺酸外流。胍基乙磺酸盐处理导致视网膜牛磺酸在体内耗竭，可能是由于其拮抗了牛磺酸从血液转运至视网膜的过程。
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