Salceda R
Neurochem Res. 1980 May;5(5):561-72. doi: 10.1007/BF00964993.
A specific system for taurine transport is present at the early stages of development in both chick and rat retinas. The results obtained with taurine analogs indicate a high degree of specificity of taurine uptake. Two transport systems were detected for the adult rat retina: a high-affinity (Km 21 microM) and a low-affinity transport system (Km 312 microM). On the other hand, in the adult chick retina, only a low-affinity transport system (Km 580 microM) could be detected. Nevertheless, embryo chick retina accumulated [3H]taurine by two different kinetic mechanisms with Kms of 242 microM and 21 microM for the low- and high-affinity processes, respectively. Taurine uptake systems were absolutely Na+ dependent. The sodium-dependence curve for taurine uptake was sigmoid. These mechanisms appear not to be mediated by a Na+ cotransport system. In spite of the differences observed in taurine uptake in both species, in each of them it closely parallels the changes brought about by the morphological and functional maturation of the retina.
在鸡和大鼠视网膜发育的早期阶段，存在一种特定的牛磺酸转运系统。用牛磺酸类似物获得的结果表明牛磺酸摄取具有高度特异性。在成年大鼠视网膜中检测到两种转运系统：一种高亲和力（Km为21微摩尔）和一种低亲和力转运系统（Km为312微摩尔）。另一方面，在成年鸡视网膜中，只能检测到一种低亲和力转运系统（Km为580微摩尔）。然而，胚胎鸡视网膜通过两种不同的动力学机制积累[3H]牛磺酸，低亲和力和高亲和力过程的Km分别为242微摩尔和21微摩尔。牛磺酸摄取系统绝对依赖于Na+。牛磺酸摄取的钠依赖性曲线呈S形。这些机制似乎不是由Na+共转运系统介导的。尽管在这两个物种中观察到牛磺酸摄取存在差异，但在每个物种中，它都与视网膜形态和功能成熟所带来的变化密切平行。
