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相似文献

1
A large inverted repeat sequence overlaps two acceptor splice sites in adenovirus.一个大的反向重复序列与腺病毒中的两个剪接受体位点重叠。
Nucleic Acids Res. 1983 Dec 20;11(24):8891-900. doi: 10.1093/nar/11.24.8891.
2
Secondary structure of splice sites in adenovirus mRNA precursors.腺病毒mRNA前体中剪接位点的二级结构。
Nucleic Acids Res. 1984 Nov 26;12(22):8437-56. doi: 10.1093/nar/12.22.8437.
3
The 216-nucleotide intron of the E1A pre-mRNA contains a hairpin structure that permits utilization of unusually distant branch acceptors.E1A前体mRNA的216个核苷酸内含子包含一个发夹结构，该结构允许使用异常遥远的分支受体。
Mol Cell Biol. 1989 Nov;9(11):4852-61. doi: 10.1128/mcb.9.11.4852-4861.1989.
4
Structural study of the 5' end of a synthetic premessenger RNA from adenovirus. Evidence for a long-range exon-intron interaction.腺病毒合成前体信使核糖核酸5'端的结构研究。远距离外显子-内含子相互作用的证据。
J Mol Biol. 1994 Jul 15;240(3):205-25. doi: 10.1006/jmbi.1994.1436.
5
Secondary structure model for the complete simian virus 50 late precursor mRNA.完整的猿猴病毒50晚期前体mRNA的二级结构模型
Nucleic Acids Res. 1982 Jan 11;10(1):351-63. doi: 10.1093/nar/10.1.351.
6
Splice site consensus sequences are preferentially accessible to nucleases in isolated adenovirus RNA.在分离出的腺病毒RNA中，剪接位点共有序列优先被核酸酶识别。
Nucleic Acids Res. 1986 Nov 11;14(21):8447-65. doi: 10.1093/nar/14.21.8447.
7
Role of the branch site/3'-splice site region in adenovirus-2 E1A pre-mRNA alternative splicing: evidence for 5'- and 3'-splice site co-operation.腺病毒2型E1A前体mRNA可变剪接中分支位点/3'-剪接位点区域的作用：5'-和3'-剪接位点协同作用的证据
Nucleic Acids Res. 1989 Feb 11;17(3):925-38. doi: 10.1093/nar/17.3.925.
8
An unstructured mRNA region and a 5' hairpin represent important elements of the E. coli translation initiation signal determined by using the bacteriophage T7 gene 1 translation start site.一个非结构化的mRNA区域和一个5'发夹结构代表了通过使用噬菌体T7基因1翻译起始位点确定的大肠杆菌翻译起始信号的重要元件。
Nucleic Acids Res. 1993 Dec 11;21(24):5705-11. doi: 10.1093/nar/21.24.5705.
9
The role of nucleotide sequences in splice site selection in eukaryotic pre-messenger RNA.核苷酸序列在真核生物前体信使RNA剪接位点选择中的作用。
Nature. 1986;324(6094):280-2. doi: 10.1038/324280a0.
10
S1 sensitive sites in adenovirus DNA.腺病毒DNA中的S1敏感位点。
Nucleic Acids Res. 1983 Jan 11;11(1):21-36. doi: 10.1093/nar/11.1.21.

引用本文的文献

1
Secondary structure of splice sites in adenovirus mRNA precursors.腺病毒mRNA前体中剪接位点的二级结构。
Nucleic Acids Res. 1984 Nov 26;12(22):8437-56. doi: 10.1093/nar/12.22.8437.
2
The different intron 2 species excised in vivo from the E2A premRNA of adenovirus-2: an approach to analyse alternative splicing.从腺病毒2型的E2A前体mRNA体内切除的不同内含子2种类：一种分析可变剪接的方法。
Nucleic Acids Res. 1986 Jul 11;14(13):5207-27. doi: 10.1093/nar/14.13.5207.
3
Amount of RNA secondary structure required to induce an alternative splice.诱导可变剪接所需的RNA二级结构量。
Mol Cell Biol. 1987 Sep;7(9):3194-8. doi: 10.1128/mcb.7.9.3194-3198.1987.
4
Splice site consensus sequences are preferentially accessible to nucleases in isolated adenovirus RNA.在分离出的腺病毒RNA中，剪接位点共有序列优先被核酸酶识别。
Nucleic Acids Res. 1986 Nov 11;14(21):8447-65. doi: 10.1093/nar/14.21.8447.
5
Antisense RNA inhibits splicing of pre-mRNA in vitro.反义RNA在体外抑制前体mRNA的剪接。
EMBO J. 1988 Aug;7(8):2523-32. doi: 10.1002/j.1460-2075.1988.tb03100.x.

本文引用的文献

1
Identification of the gene and mRNA for the adenovirus terminal protein precursor.腺病毒末端蛋白前体的基因和信使核糖核酸的鉴定。
Cell. 1981 Feb;23(2):497-508. doi: 10.1016/0092-8674(81)90145-8.
2
Are snRNPs involved in splicing?小核核糖核蛋白颗粒参与剪接过程吗？
Nature. 1980 Jan 10;283(5743):220-4. doi: 10.1038/283220a0.
3
Speculations on RNA splicing.关于RNA剪接的推测。
Cell. 1981 Mar;23(3):643-6. doi: 10.1016/0092-8674(81)90425-6.
4
Nucleotide sequences from the adenovirus-2 genome.来自腺病毒2型基因组的核苷酸序列。
J Biol Chem. 1982 Nov 25;257(22):13475-91.
5
A catalogue of splice junction sequences.剪接连接序列目录。
Nucleic Acids Res. 1982 Jan 22;10(2):459-72. doi: 10.1093/nar/10.2.459.
6
Eukaryotic DNA replication: viral and plasmid model systems.真核生物DNA复制：病毒和质粒模型系统
Annu Rev Biochem. 1982;51:901-34. doi: 10.1146/annurev.bi.51.070182.004345.
7
Nucleotide sequence of adenovirus 2 DNA fragment encoding for the carboxylic region of the fiber protein and the entire E4 region.编码纤维蛋白羧基区域和整个E4区域的腺病毒2型DNA片段的核苷酸序列。
Nucleic Acids Res. 1981 Aug 25;9(16):4023-42. doi: 10.1093/nar/9.16.4023.
8
RNA splicing in neurospora mitochondria: structure of the unspliced 35S precursor ribosomal RNA detected by psoralen cross-linking.粗糙脉孢菌线粒体中的RNA剪接：通过补骨脂素交联检测到的未剪接35S前体核糖体RNA的结构
Cell. 1983 Feb;32(2):397-407. doi: 10.1016/0092-8674(83)90459-2.
9
Pattern recognition in nucleic acid sequences. I. A general method for finding local homologies and symmetries.核酸序列中的模式识别。I. 寻找局部同源性和对称性的通用方法。
Nucleic Acids Res. 1982 Jan 11;10(1):247-63. doi: 10.1093/nar/10.1.247.
10
Organization and expression of eucaryotic split genes coding for proteins.编码蛋白质的真核生物断裂基因的组织与表达。
Annu Rev Biochem. 1981;50:349-83. doi: 10.1146/annurev.bi.50.070181.002025.

一个大的反向重复序列与腺病毒中的两个剪接受体位点重叠。

A large inverted repeat sequence overlaps two acceptor splice sites in adenovirus.

作者信息

Munroe S H

出版信息

Nucleic Acids Res. 1983 Dec 20;11(24):8891-900. doi: 10.1093/nar/11.24.8891.

DOI:10.1093/nar/11.24.8891
PMID:6672774
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC326632/
Abstract

The distribution of nucleotide sequences resembling functional sites for mRNA splicing was examined by computer-directed searches in order to determine what factors may influence splice site selection in nuclear precursors. In particular, the distribution of large potentially stable hairpin structures or regions of extensive dyad symmetry was studied in adenovirus sequences. One region, spanning 106 nucleotides, was found at 66.4 map units, overlapping back-to-back acceptor sites for two mRNA molecules, those coding for the 100K protein and the 72K DNA binding protein, which are transcribed from opposite strands. This region displays exceptional dyad symmetry and is potentially capable of forming a single, highly stable hairpin when transcribed. It seems likely that the secondary structure as well as the primary structure of RNA plays a role in determining the correct splicing of these mRNA molecules.

摘要

通过计算机定向搜索来检查类似于mRNA剪接功能位点的核苷酸序列分布，以确定哪些因素可能影响核前体中的剪接位点选择。特别是，研究了腺病毒序列中大型潜在稳定发夹结构或广泛二元对称区域的分布。在66.4个图谱单位处发现了一个跨度为106个核苷酸的区域，它与两个mRNA分子的背对背受体位点重叠，这两个mRNA分子分别编码100K蛋白和72K DNA结合蛋白，它们从相反的链转录而来。该区域表现出异常的二元对称性，转录时可能能够形成一个高度稳定的单发卡结构。RNA的二级结构以及一级结构似乎在决定这些mRNA分子的正确剪接中发挥作用。