Raub J A, Mercer R R, Kavlock R J, Setzer C J
Prog Clin Biol Res. 1983;140:119-34.
The herbicide Nitrofen was administered by gavage to pregnant F-344 rats during Days 10 through 13 of gestation. Postnatal lung function was measured in male progeny at 3 and 6 weeks of age. There were no differences in body weight or wet and dry lung weights between control and Nitrofen-exposed rats in either age group. Nitrofen produced no observable effects on lung function at 3 weeks of age. However, by 6 weeks of age the Nitrofen-exposed animals had significant decreases in tidal volume (p less than 0.01), vital capacity (p less than 0.01), total lung capacity (p less than 0.05), and quasi-static lung compliance (p less than 0.01). There was also a mild ventilation inhomogeneity, as indicated by significant increases in the nitrogen washout slope (p less than 0.01) and the moment ratio (p less than 0.05). Histopathology of lung, liver, kidney, and testes was not significantly altered by Nitrofen exposure. These data suggest that prenatal Nitrofen exposure may have an effect on postnatal lung maturation in the rat and could potentially be useful as a model of pulmonary hypoplasia.
在妊娠第10至13天，通过灌胃法给怀孕的F-344大鼠施用除草剂除草醚。在3周龄和6周龄时测量雄性后代的产后肺功能。在两个年龄组中，对照组和接触除草醚的大鼠之间的体重、肺湿重和干重均无差异。除草醚在3周龄时对肺功能没有产生可观察到的影响。然而，到6周龄时，接触除草醚的动物的潮气量（p<0.01）、肺活量（p<0.01）、肺总量（p<0.05）和准静态肺顺应性（p<0.01）均显著下降。如氮洗脱斜率（p<0.01）和矩比（p<0.05）显著增加所示，还存在轻度通气不均匀性。接触除草醚并未显著改变肺、肝、肾和睾丸的组织病理学。这些数据表明，产前接触除草醚可能对大鼠产后肺成熟有影响，并有可能作为肺发育不全的模型。
