硝芬对T3受体结合的抑制作用。

Inhibition of T3-receptor binding by Nitrofen.

作者信息

Brandsma A E, Tibboel D, Vulto I M, de Vijlder J J, Ten Have-Opbroek A A, Wiersinga W M

机构信息

Department of Pediatric Surgery, University of Rotterdam, The Netherlands.

出版信息

Biochim Biophys Acta. 1994 Nov 11;1201(2):266-70. doi: 10.1016/0304-4165(94)90050-7.

DOI:10.1016/0304-4165(94)90050-7

PMID:7947941

Abstract

Lung development is controlled by various hormones, including thyroid hormone. The herbicide 2,4-dichlorophenyl-p-nitrophenyl ether (Nitrofen) induces lung hypoplasia in fetal rats, when administered to the mother during gestation. Nitrofen might be teratogenic by an anti-thyroid activity. The present study shows that Nitrofen decreases the binding of T3 to the alpha 1 and beta 1 form of the thyroid hormone receptor in a non-competitive way. Consequently, rat lung hypoplasia might result from the decreased binding of T3 to its receptor, via exposure to Nitrofen during fetal development.

摘要

肺的发育受多种激素控制，包括甲状腺激素。除草剂2,4-二氯苯基对硝基苯醚（除草醚）在孕期给予母鼠时，可诱导胎鼠肺发育不全。除草醚可能通过抗甲状腺活性而具有致畸性。本研究表明，除草醚以非竞争性方式降低T3与甲状腺激素受体α1和β1形式的结合。因此，胎鼠肺发育不全可能是由于在胎儿发育期间接触除草醚，导致T3与其受体的结合减少所致。