甲氨蝶呤在体外诱导L1210细胞糖酵解改变。
Methotrexate induced alteration of glycolysis in L1210 cells in vitro.
作者信息
Desoize B, Carpentier Y, Jardillier J C
出版信息
Biomedicine. 1978 Apr;29(2):58-60.
PMID:667290
Abstract
Methotrexate, in non-lethal doses, greatly enhances anaerobic glycolysis in L1210 cells. Lactate/glucose ratio remains constant but intracellular levels of glycolytic enzymes are increased. ATP accumulating in the cells seems to reflect an alteration of regulation of the glycolysis.
摘要
非致死剂量的甲氨蝶呤能显著增强L1210细胞的无氧糖酵解。乳酸/葡萄糖比值保持恒定，但糖酵解酶的细胞内水平增加。细胞中积累的ATP似乎反映了糖酵解调节的改变。
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