[甲氨蝶呤对体外培养的白血病L 1210细胞糖酵解的影响]
[Effect of methotrexate on glycolysis of leukemia L 1210 cells cultivated in vitro].
作者信息
Carpentier Y, Desoize B, Rollet C, Jardillier J C
出版信息
C R Acad Hebd Seances Acad Sci D. 1978 Jan 30;286(4):375-7.
PMID:418900
Abstract
Methotrexate, at non lethal doses, alters the glycolysis of leukaemic L 1210 cells. Glucose uptake and lactate excretion are increased but lactate/glucose ratio remains constant. The activity of glycolytic enzymes in the cytoplasm is increased and the level of intracellular ATP is greatly enhanced.
摘要
非致死剂量的甲氨蝶呤会改变白血病L 1210细胞的糖酵解过程。葡萄糖摄取和乳酸排泄增加，但乳酸/葡萄糖比值保持恒定。细胞质中糖酵解酶的活性增加，细胞内ATP水平大幅提高。
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