3,4-二氨基吡啶。一种强效的新型钾通道阻滞剂。
3,4-diaminopyridine. A potent new potassium channel blocker.
作者信息
Kirsch G E, Narahashi T
出版信息
Biophys J. 1978 Jun;22(3):507-12. doi: 10.1016/S0006-3495(78)85503-9.
Abstract
3,4-diaminopyridine has been found to act very potently in selectively blocking the potassium channels of squid axon membranes. The apparent dissociation constants for this action are estimated to be 5.8 micron and 0.7 micron for external and internal applications, respectively, the potency being about 50 times higher than that of 4-aminopyridine. The block depends upon the membrane potential, time, and stimulus frequency. 3,4-diaminopyridine shows great promise as a useful tool for the study of membrane ionic channels.
摘要
已发现3,4-二氨基吡啶能非常有效地选择性阻断乌贼轴突膜的钾通道。这种作用的表观解离常数，外部应用时估计为5.8微米，内部应用时为0.7微米，其效力比4-氨基吡啶高约50倍。这种阻断作用取决于膜电位、时间和刺激频率。3,4-二氨基吡啶作为研究膜离子通道的一种有用工具，显示出巨大的前景。
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