Marks W H, Ohlsson K
Scand J Gastroenterol. 1983 May;18(3):401-5. doi: 10.3109/00365528309181614.
A radioimmunoassay for the detection of pancreatic secretory trypsin inhibitor (PSTI) in the rat is described. The sensitivity of the assay enables the specific measurement of this inhibitor in the serum of normal rats. The average base-line value for multiple animal serum specimens taken from fasting female Wistar rats being fed conventional diets was 11.6 +/- 6.2 micrograms/l. The inhibitor existed in its free form in serum, and PSTI immunoreactivity increased significantly within 2 h of the induction of experimental pancreatitis. The present assay will facilitate the study of PSTI in experimental diseases of the pancreas.
本文描述了一种用于检测大鼠胰腺分泌性胰蛋白酶抑制剂（PSTI）的放射免疫测定法。该测定法的灵敏度能够特异性地测量正常大鼠血清中的这种抑制剂。从喂食常规饮食的禁食雌性Wistar大鼠采集的多个动物血清样本的平均基线值为11.6±6.2微克/升。该抑制剂以游离形式存在于血清中，并且在实验性胰腺炎诱导后2小时内PSTI免疫反应性显著增加。本测定法将有助于胰腺实验性疾病中PSTI的研究。
