Amroian E A, Gabrielian E S
Biull Eksp Biol Med. 1978 Mar;85(3):307-10.
A resistographic study of the cerebrovascular resistance (CVR) and of the arterial blood pressure showed prostaglandins (PG), type E, to inhibit the pressor action of tyramine on the cerebral vessels and the blood pressure. Indomethacin--an inhibitor of PG biosynthesis, retarded the tyramine tachyphylaxis and restored its pressor effect. Ipraside, the monoaminooxidase inhibitor, failed to influence the speed of tyramine tachyphylaxis development under conditions of indomethacin infusion, but increased the pressor effect of tyramine. It is supposed that inomethacin influence was based on the hypersensitivity of the vascular adrenoreceptors.
一项关于脑血管阻力（CVR）和动脉血压的电阻抗图研究表明，E型前列腺素（PG）可抑制酪胺对脑血管和血压的升压作用。吲哚美辛——一种PG生物合成抑制剂，可延缓酪胺快速耐受性的发展并恢复其升压作用。单胺氧化酶抑制剂异哌啶在输注吲哚美辛的情况下未能影响酪胺快速耐受性发展的速度，但增强了酪胺的升压作用。据推测，吲哚美辛的影响是基于血管肾上腺素能受体的超敏反应。
