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[下丘脑视上区电刺激对脂质代谢及动脉粥样硬化发展的影响]

[Effect of electrostimulation of the supraoptic region of the hypothalamus on lipid metabolism and the development of atherosclerosis].

作者信息

Zavodskaia I S, Moreva E V, Sinitsyna T A, Ryzhenkov V E, Nikul'cheva N G

出版信息

Biull Eksp Biol Med. 1978 Jun;85(6):661-4.

PMID:667340
Abstract

A three-week electrical stimulation of the hypothalamic supraoptic zone in rabbits which were on atherogenic diet for 3 to 8 weeks accelerated and intensified the development of hypercholesterolemia and lipidosis of the coronary arteries, as well as the metabolic changes in the myocardial tissue. The latter changes were expressed in the reduction of the tissue noradrenaline level, diminution of the creatine phosphate content, and an increase of inorganic phosphorus and lactic acid.

摘要

对食用致动脉粥样化饮食3至8周的家兔下丘脑视上区进行为期三周的电刺激,加速并加剧了高胆固醇血症和冠状动脉脂质沉积的发展,以及心肌组织的代谢变化。后者的变化表现为组织去甲肾上腺素水平降低、磷酸肌酸含量减少,以及无机磷和乳酸增加。

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1
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Biull Eksp Biol Med. 1978 Jun;85(6):661-4.
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