Negoescu I, Constantinescu A, Zamfir-Grigorescu D, Simescu M
Endocrinologie. 1977 Jan-Mar;15(1):35-40.
The effects of a single dose and of 5 doses (5 days) of a bovine polypeptide pineal extract (PE) on the pituitary TSH reserves and on the blood level of thyroid hormones were studied on hypothyroid patients. The blood levels of PBI, total T4 (radiocompetitive), free T4, T3 and TSH (RIA) in basal conditions and during the TRH test (i.v. administration of 200 mug TRH), In the presence and absence of the treatment with PE were determined. Thirty minutes following i.m. administration of PE a decrease was noticed in the high level of the basal TSH in all the patients as well as maintenance or even exaggeration of the TRH response. After 5 days of PE administration a decrease was noticed in the basal TSH, with preservation of a strong response of the TSH release after TRH administration. In these patients a slight decrease was observed in PBI, total and free T4 and T3, when their initial level was close to normal. The results show the results show the intervention of the pineal extract by inhibiting the endogenous TRH.
对甲状腺功能减退患者研究了单次剂量及5次剂量（5天）的牛松果体多肽提取物（PE）对垂体促甲状腺激素储备及甲状腺激素血水平的影响。测定了在基础状态下以及在促甲状腺激素释放激素（TRH）试验（静脉注射200μg TRH）期间，在给予和未给予PE治疗的情况下，患者的蛋白结合碘（PBI）、总T4（放射竞争法）、游离T4、T3及促甲状腺激素（TSH，放射免疫分析法）的血水平。肌肉注射PE 30分钟后，所有患者基础TSH的高水平均下降，同时TRH反应维持甚至增强。给予PE 5天后，基础TSH下降，TRH给药后TSH释放仍有强烈反应。在这些患者中，当初始水平接近正常时，观察到PBI、总T4、游离T4及T3略有下降。结果表明松果体提取物通过抑制内源性TRH发挥作用。
