Miggiano G A, Mordente A, Martorana G E, Meucci E, Castelli A
Acta Vitaminol Enzymol. 1983;5(4):219-24.
The organ-specific modulation by ascorbic acid and related compounds on alkaline phosphatase activity of calf intestinal and human placental tissues has been studied at pH 8.0 and 37 degrees C. L(+)-ascorbic acid and its isomer D(-)-ascorbic acid inhibit to a similar extent the intestinal isoenzyme and appear to be more potent modifiers than dehydro-L-(+)-ascorbic acid. In contrast, the placental isoenzyme shows an initial activation by the three chemical agents, followed by an inhibition. The inhibition is lower with L(+)-ascorbic acid and D(-)-ascorbic acid, while its catalytic activity is affected only slightly by dehydro-L-(+)ascorbic acid.
在pH 8.0和37摄氏度条件下，研究了抗坏血酸及相关化合物对小牛肠和人胎盘组织碱性磷酸酶活性的器官特异性调节作用。L(+)-抗坏血酸及其异构体D(-)-抗坏血酸对肠同工酶的抑制程度相似，并且似乎比脱氢-L-(+)-抗坏血酸更具强效调节作用。相比之下，胎盘同工酶在这三种化学试剂作用下先表现出激活，随后受到抑制。L(+)-抗坏血酸和D(-)-抗坏血酸的抑制作用较弱，而脱氢-L-(+)抗坏血酸对其催化活性的影响较小。
