Escalier D
Biol Cell. 1983;48(1):65-74. doi: 10.1111/j.1768-322x.1984.tb00203.x.
Macrocephalic spermatozoa of six men were studied. In all cases, sperm concentration, proportion of live spermatozoa and sperm motility were very low. A range of ultrastructural abnormalities was found, essentially comprising a threefold increase in nuclear volume and acrosomal hyperdevelopment and malformation. There were on average 3.6 flagella for each sperm head found in the semen, some tails were separate from heads. The various defects appeared with great constancy in all of the six cases: this homogeneity indicated the existence of a defined semen profile whose most significant expression was sterility. In four of the cases large incidences of different flagellar abnormalities were also noted; whether these flagellar abnormalities are intrinsic to the above profile is not clear. Although the increase in nuclear volume suggests a disturbance in meiosis, its association with defective nuclear elongation would also indicate the existence of one or more anomalies of spermiogenesis. These results were discussed in relation to abnormalities already reported in other species either spontaneously in cases of mutations, or by experimental inhibition of microtubular structures.
对六名男性的大头精子进行了研究。在所有病例中，精子浓度、活精子比例和精子活力都非常低。发现了一系列超微结构异常，主要包括核体积增加三倍以及顶体过度发育和畸形。精液中每个精子头部平均有3.6条鞭毛，有些尾巴与头部分离。在所有六例病例中，各种缺陷都非常恒定地出现：这种同质性表明存在一种明确的精液特征，其最显著的表现是不育。在其中四例病例中，还注意到不同鞭毛异常的发生率很高；这些鞭毛异常是否是上述特征所固有的尚不清楚。虽然核体积的增加表明减数分裂受到干扰，但其与核伸长缺陷的关联也表明存在一种或多种精子发生异常。结合其他物种中已报道的自发突变病例或通过实验抑制微管结构而出现的异常情况，对这些结果进行了讨论。
