Giordana M T, Mauro A, Migheli A, Schiffer D
Ital J Neurol Sci. 1983 Dec;4(4):411-5. doi: 10.1007/BF02125619.
The problem of differentiation of medulloblastoma is considered. In this regard 43 medulloblastomas, showing cells with glial or neuronal features by routine histologic methods, were studied. The investigation was carried out by means of the immunohistochemical demonstration of the glial fibrillary acidic protein (GFAP) and the neuron-specific enolase (NSE). In most cases, GFAP-positive cells are preexisting astrocytes; in two cases they correspond to the transitional cells of the subependymal layer. NSE was demonstrated in areas filled with cells with neuroblastic features. The relationship between medulloblastoma with neuron-differentiation and cerebellar neuroblastoma is discussed.
本文探讨了髓母细胞瘤的分化问题。在此方面，对43例通过常规组织学方法显示具有神经胶质或神经元特征细胞的髓母细胞瘤进行了研究。研究采用免疫组织化学方法检测胶质纤维酸性蛋白（GFAP）和神经元特异性烯醇化酶（NSE）。在大多数情况下，GFAP阳性细胞为既存的星形胶质细胞；在两例中，它们对应于室管膜下层的过渡细胞。在充满具有成神经细胞特征细胞的区域检测到了NSE。文中还讨论了具有神经元分化的髓母细胞瘤与小脑成神经细胞瘤之间的关系。
