Schiffer D, Giordana M T, Mauro A, Migheli A
Tumori. 1983 Apr 30;69(2):95-104. doi: 10.1177/030089168306900203.
Glial fibrillary acidic protein (GFAP) was studied in 160 cerebral tumors, mostly of neuro-epithelial nature. It was positive in astroglial tumors with an intensity proportional to the degree of cell differentiation. It was sometimes positive also in non-astroglial tumors, such as oligodendrogliomas and ependymomas, and this finding is discussed in relation to genesis and diagnostic value. In medulloblastomas, there were also positive cells, which could be reactive glia cells included in the tumors or subependymal cells. The demonstration of GFAP is very useful in gliosarcomas for identifying the glial component. It was sometimes positive in hemangioblastomas, and it is discussed in view of the nature of the stromal cells of this tumor.
对160例脑肿瘤（大多为神经上皮性质）进行了胶质纤维酸性蛋白（GFAP）研究。在星形胶质细胞瘤中呈阳性，其强度与细胞分化程度成正比。在非星形胶质细胞瘤，如少突胶质细胞瘤和室管膜瘤中有时也呈阳性，本文结合其发生及诊断价值对这一发现进行了讨论。在髓母细胞瘤中也有阳性细胞，可能是肿瘤中包含的反应性胶质细胞或室管膜下细胞。GFAP的显示对识别胶质肉瘤中的胶质成分非常有用。在成血管细胞瘤中有时呈阳性，本文根据该肿瘤基质细胞的性质进行了讨论。
