Nakamura S, Morioka S, Baba S, Maeda M, Muro H
Nihon Geka Gakkai Zasshi. 1983 Feb;84(2):135-40.
Massive hepatic resection was carried out on a 42 year-old female who had metastatic lesions of the colonic cancer in right lobe of the liver, which was accompanied by Dubin-Johnson syndrome. The following observations were made. Patient with Dubin-Johnson syndrome tolerated major hepatectomy. As for postoperative regeneration of the liver, there was no difference in comparison with the normal liver. Dubin-Johnson pigments in the hepatocytes decreased in proportion to hepatic regeneration for two months after hepatectomy. Therefore, it might be concluded that Dubin-Johnson syndrome is not poor risk factor for major surgery and massive hepatic resection.
对一名42岁患有结肠癌肝右叶转移灶且伴有杜宾-约翰逊综合征的女性患者实施了大范围肝切除术。观察结果如下。患有杜宾-约翰逊综合征的患者耐受了大肝切除术。至于术后肝脏再生情况，与正常肝脏相比并无差异。肝切除术后两个月，肝细胞内的杜宾-约翰逊色素随着肝脏再生而按比例减少。因此，可以得出结论，杜宾-约翰逊综合征并非大手术及大范围肝切除术的高风险因素。
