Lapierre Y D, Bulmer D R, Oyewumi L K, Mauguin M L, Knott V J
Neuropsychobiology. 1983;10(2-3):127-30. doi: 10.1159/000117998.
This study was carried out to compare the efficacy of chlormethiazole and chlordiazepoxide in the treatment of acute alcohol withdrawal syndrome in 40 patients. Repeated biochemical, clinical, and psychophysiological measurements were obtained in a randomized, double-blind design in which one group of patients received chlormethiazole and a second group received chlordiazepoxide over a period of 7 days. Analysis indicated both drugs to be of equivalent potency and were equally well tolerated by patients. The more severe aspects of withdrawal were brought under control within the first 4 days of treatment. However, even at 7 days, there still persisted some symptoms attributable to the withdrawal from alcohol.
本研究旨在比较氯美噻唑和氯氮䓬治疗40例急性酒精戒断综合征患者的疗效。采用随机双盲设计，对患者进行反复的生化、临床及心理生理测量，一组患者接受氯美噻唑治疗，另一组接受氯氮䓬治疗，为期7天。分析表明两种药物效力相当，患者耐受性也相同。戒断较严重的症状在治疗的前4天内得到控制。然而，即使在7天时，仍存在一些因戒酒所致的症状。
