Gemer O, Zaltztein E, Gorodischer R
Pediatr Pharmacol (New York). 1983;3(2):119-23.
The use of oral gentamicin in infantile diarrhea is recommended by some authors. However, no data are available concerning the gastrointestinal absorption of gentamicin in infants when the mucosa of the small intestine is damaged. In this study, plasma gentamicin concentrations were measured in 14 infants suffering from prolonged diarrhea and treated with oral gentamicin (mean dose: 17 mg/kg every 8 hr). Plasma gentamicin levels were determined serially following the oral dose. Although marked individual and erratic temporal variations existed, average plasma gentamicin concentrations were low and stable (0.31 +/- 0.12 micrograms/ml). A positive correlation was found between the duration of the diarrhea and plasma gentamicin concentrations (r = 0.59, P less than 0.05). It is theorized that the damage to the mucosa as it occurs in prolonged diarrhea allows the absorption of the polar gentamicin molecule.
一些作者推荐在婴儿腹泻时使用口服庆大霉素。然而，当小肠黏膜受损时，关于婴儿对庆大霉素的胃肠道吸收情况尚无可用数据。在本研究中，对14例患有迁延性腹泻并接受口服庆大霉素治疗（平均剂量：每8小时17mg/kg）的婴儿测定了血浆庆大霉素浓度。口服给药后连续测定血浆庆大霉素水平。尽管存在明显的个体差异和不稳定的时间变化，但平均血浆庆大霉素浓度较低且稳定（0.31±0.12μg/ml）。腹泻持续时间与血浆庆大霉素浓度之间存在正相关（r = 0.59，P＜0.05）。据推测，迁延性腹泻时发生的黏膜损伤使得极性庆大霉素分子得以吸收。
