Fujii T, Tamura A
Biomed Biochim Acta. 1983;42(11-12):S81-5.
Shape change (crenation, echinocyte formation) of intact human erythrocytes induced by added phosphatidylcholine or lysophosphatidylcholine species with varying acyl chain lengths was dependent only on the amount of the lipid incorporated into the membrane (determined with 14C-labelled lipids), irrespective of the chain length. The chain length appears to determine the speed and the maximal extent of the lipid transfer from the outside medium into the membrane. The altered shape gradually reverted upon incubation at 37 degrees C, not at low temperature, until the cells reassumed their normal shape. Translocation of the incorporated lipid molecules from the outer to the inner leaflet of the membrane lipid bilayer occurred to a slight extent during the incubation.
添加不同酰基链长度的磷脂酰胆碱或溶血磷脂酰胆碱导致完整人红细胞的形状改变（皱缩、棘红细胞形成）仅取决于掺入膜中的脂质数量（用14C标记的脂质测定），而与链长度无关。链长度似乎决定了脂质从外部介质转移到膜中的速度和最大程度。在37℃孵育时，改变的形状会逐渐恢复，而在低温下则不会，直到细胞恢复其正常形状。在孵育过程中，掺入的脂质分子会从膜脂双层的外层轻微转移到内层。
