Hashimoto K, Akaogi E, Suda H, Saito Y, Imai T, Nakada T
Nihon Geka Gakkai Zasshi. 1983 Sep;84(9):771-3.
The microscopic metastases were examined seemingly unaffected areas of the resected lungs in 116 primary lung cancer patients. In 55 patients (47%), micrometastases were found in the areas which looked normal. The investigation on the route and location of micrometastaes revealed that lung metastases were formed mainly through haematogenous and partly through lymphatic route. The high incidence of postoperative intrapulmonary spread in the positive micrometastasis group suggested that most of microscopic deposits would become distinct tumors in time. Thirteen patients have had a second operation for the intrapulmonary metastatic lesions. There was one postoperative death. Nine patients have subsequently died. Three patients are still alive and well without evidence of recurrence.
对116例原发性肺癌患者切除肺的看似未受影响区域进行了微小转移灶检查。在55例患者（47%）中，在看似正常的区域发现了微转移灶。对微转移灶的途径和位置进行的研究表明，肺转移主要通过血行途径形成，部分通过淋巴途径形成。微转移阳性组术后肺内播散的高发生率表明，大多数微小沉积物最终会形成明显的肿瘤。13例患者因肺内转移灶接受了二次手术。术后有1例死亡。9例患者随后死亡。3例患者仍存活且情况良好，无复发迹象。
