Oliverio A, Castellano C, Pavone F, Vetulani J
Pol J Pharmacol Pharm. 1983 Nov-Dec;35(6):445-9.
In C57BL/6 mice caffeine antagonized morphine-induced hyperactivity. This effect was most evident when caffeine was used in doses that slightly increased locomotor activity. Given at the same dose caffeine did not affect morphine-induced analgesia. Two possibilities of explanation of this effect are discussed: action of caffeine on dopaminergic mechanisms responsible for morphine-induced running fit through its effect on cyclic AMP level, and a direct action of caffeine on delta opiate receptors involved in the stimulatory effect of morphine.
在C57BL/6小鼠中，咖啡因可拮抗吗啡诱导的多动。当使用略微增加运动活性的剂量的咖啡因时，这种作用最为明显。以相同剂量给予时，咖啡因不影响吗啡诱导的镇痛作用。文中讨论了对此作用的两种可能解释：咖啡因通过其对环磷酸腺苷水平的影响作用于负责吗啡诱导的奔跑发作的多巴胺能机制，以及咖啡因对参与吗啡刺激作用的δ阿片受体的直接作用。
