Sansone M, Pavone F, Battaglia M, Vetulani J
Istituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
Pol J Pharmacol. 1995 Sep-Oct;47(5):387-92.
The effect of diazepam on locomotor activity was tested by measuring the number of crossings between two compartments of a toggle-floor box, in control mice (water drinking) and in mice receiving caffeine solution (0.5 g/I) instead of drinking water. In control mice, diazepam did not produce any significant change in total activity measured on the whole 60-min test, but animals showed phases of increased activity broken by periods of immobility. After chronic ingestion (18 days) of caffeine, doses of 0.5, 1 and 2 mg/kg ip diazepam significantly increased total locomotor activity. Caffeine slightly reduced diazepam-induced immobility and increased the frequency of crossings in active periods. Taken together, these two effects may explain the significant increase in total activity induced by diazepam in caffeine-treated mice. Mixed stimulatory-depressant action was also produced by 3 mg/kg diazepam, a dose that slightly decreased the total activity.
通过测量控制组小鼠（饮用纯水）和饮用咖啡因溶液（0.5 g/I）而非纯水的小鼠在翻转地板箱两个隔室间的穿越次数，来测试地西泮对运动活性的影响。在控制组小鼠中，地西泮在整个60分钟测试期间所测得的总活性未产生任何显著变化，但动物表现出活动增加期被静止期打断的情况。在长期摄入（18天）咖啡因后，腹腔注射0.5、1和2 mg/kg剂量的地西泮显著增加了总运动活性。咖啡因轻微减少了地西泮诱导的静止期，并增加了活动期的穿越频率。综合来看，这两种效应可能解释了在咖啡因处理的小鼠中地西泮诱导的总活性显著增加的原因。3 mg/kg剂量的地西泮也产生了混合的兴奋-抑制作用，该剂量略微降低了总活性。
