Synthesis and antileukemic properties of 2-methyl and 2,5-dimethylpiperazides.

New piperazides 1-15 were synthesized as analogues of an agent active against Leukemia 1210, 4.4'-(2-methyl-1,4- piperazinediyl )-bis-(4-oxo)-2- butenoic acid diethyl ester, NG (NSC 337310). The piperazides were synthesized by treatment of 2-methyl or 2,5-dimethyl-piperazine with maleic acid ester chlorides in CH2Cl2 or in aqueous medica in the presence of anhydr . K2CO3 . The influence of compound NG (NSC 337310) and several new derivatives on P 388 Lymphocytic Leukemia was tested: only compound NG have demonstrated a satisfactory activity.