潜在抗肿瘤剂：对-N，N-双（2-氯乙基）氨基苯乙酸的甾体双内酰胺酯
Potential antitumor agent: steroidal bilactam ester of p-N, N-bis (2-chloroethyl) aminophenylacetic acid.
作者信息
Catsoulacos P, Camoutsis C, Papageorgiou A
机构信息
University of Patras, School of Health and Sciences, Department of Pharmacy, Greece.
出版信息
Anticancer Res. 1995 May-Jun;15(3):827-30.
7 alpha-, 17 alpha-Diaza-7, 17-dioxo-B, D-dihomo-5-androsten 3 beta-p-N, N-bis (2- chloroethyl)aminophenylacetate, a modified steroidal alkylating agent, is active in the treatment of P388 and L1210 leukemias in vivo. The compound was also tested in vitro against L1210 and P388 leukemias, on DNA, RNA and protein synthesis and showed high inhibition effect. Also increases the frequency of Sister Chromatid Exchanges and reduces the replication index of human lymphocytes.
7α-，17α-二氮杂-7，17-二氧代-B，D-双高-5-雄甾烯-3β-p-N，N-双（2-氯乙基）氨基苯乙酸酯，一种改良的甾体烷基化剂，在体内对P388和L1210白血病的治疗具有活性。该化合物还在体外针对L1210和P388白血病进行了DNA、RNA和蛋白质合成测试，并显示出高抑制作用。还增加了姐妹染色单体交换的频率并降低了人淋巴细胞的复制指数。
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