Crawley W A, Levin L S
Cancer. 1978 Jul;42(1):357-63. doi: 10.1002/1097-0142(197807)42:1<357::aid-cncr2820420154>3.0.co;2-h.
Treatment of the ameloblastoma should be re-evaluated based on microscopic behavior. We suggest that conservative therapy is the initial treatment of choice. Although medullary bone is invaded by tumor cells, compact bone only is eroded. Therefore, treatment should be directed at removal of involved medullary bone, leaving as much medial and lateral cortical plates and inferior mandibular border as possible. Four patients with ameloblastoma treated conservatively are presented. Evaluation from 21 months to seven years after initial therapy revealed marked bone regeneration. Three of the four had smaller lesions remaining, requiring less radical surgery than would normally have been performed initially. No tumor was evident on rebiopsy of the fourth patient. Conservative treatment and proper follow-up were acceptable methods of initial treatment in our cases.
应根据显微镜下表现重新评估成釉细胞瘤的治疗方法。我们建议保守治疗是首选的初始治疗方法。虽然肿瘤细胞侵犯了髓质骨，但仅密质骨受到侵蚀。因此，治疗应针对切除受累的髓质骨，尽可能保留更多的内侧和外侧皮质板以及下颌下缘。本文介绍了4例接受保守治疗的成釉细胞瘤患者。初始治疗后21个月至7年的评估显示有明显的骨再生。4例中有3例残留较小的病变，与最初通常需要进行的手术相比，所需的根治性手术较少。第4例患者再次活检时未发现肿瘤。在我们的病例中，保守治疗和适当的随访是可接受的初始治疗方法。
