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二丙酸雌二醇对帕克斯(P)小鼠子宫和阴道糖原含量的影响。

Effect of estradiol dipropionate on uterine and vaginal glycogen content of Parkes (P) mice.

作者信息

Tripathi G

出版信息

Indian J Physiol Pharmacol. 1983 Oct-Dec;27(4):317-22.

PMID:6678239
Abstract

Administration of estradiol dipropionate (20 micrograms/day: for 7 days) to ovariectomized (7 days) mice produced about three fold increase (180%) in uterine glycogen content while approximately four fold decrease (76%) in vaginal glycogen as compared to their control values. Differences in glycogen content after 7 and 14 days of ovariectomy were statistically insignificant in both the organs. Although estradiol dipropionate had a great effect on the glycogen content of uterus and vagina but this effect remained more or less unchanged after causing alteration in duration (7 and 14 days) of estradiol dipropionate treatment in relation to different time intervals (7 and 14 days) after ovariectomy. So there was no time dependent response in uterine and vaginal glycogen content after 7 days onwards either in relation to ovariectomy or estradiol dipropionate treatment. The opposite trend (increase in uterus and decrease in vagina) of glycogen content in response to estradiol dipropionate may be possibly due to a greater accumulation (than utilization) in uterus while greater consumption (than accumulation) in vagina.

摘要

给去卵巢(7天)的小鼠注射二丙酸雌二醇(20微克/天,持续7天),与对照值相比,子宫糖原含量增加了约三倍(180%),而阴道糖原含量则减少了约四倍(76%)。去卵巢7天和14天后,两个器官中糖原含量的差异在统计学上不显著。尽管二丙酸雌二醇对子宫和阴道的糖原含量有很大影响,但在改变二丙酸雌二醇治疗持续时间(7天和14天)后,相对于去卵巢后的不同时间间隔(7天和14天),这种影响或多或少保持不变。因此,在去卵巢7天后,无论是相对于去卵巢还是二丙酸雌二醇治疗,子宫和阴道糖原含量都没有时间依赖性反应。二丙酸雌二醇引起的子宫和阴道糖原含量的相反趋势(子宫增加而阴道减少)可能是由于子宫中积累(多于利用)较多,而阴道中消耗(多于积累)较多。

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Effect of estradiol dipropionate on uterine and vaginal glycogen content of Parkes (P) mice.二丙酸雌二醇对帕克斯(P)小鼠子宫和阴道糖原含量的影响。
Indian J Physiol Pharmacol. 1983 Oct-Dec;27(4):317-22.
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