Raizada R B, Misra P, Saxena P, Datta K K, Dikshith T S
J Toxicol Environ Health. 1980 May;6(3):483-92. doi: 10.1080/15287398009529867.
Administration of lindane (20 mg/kg . d) for 30 d to ovariectomized rats caused no significant change in the weight of the uterus, cervix, or vagina. Histological changes in these organs were comparable to those in ovariectomized control rats. Treatment with estradiol dipropionate alone and in combination with lindane induced a significant increase in the weights of these organs. Microscopically, these organs appeared normal. Lindane induced a significant increase in the glycogen content of the uterus, cervix, and vagina of ovariectomized rats compared to ovariectomized control rats, whereas a two- to fourfold increase in glycogen was observed in ovariectomized rats treated with estradiol dipropionate or estradiol dipropionate plus lindane. There was a significant increase in total erythrocytes and hemoglobin in ovariectomized rats treated with lindane, estradiol dipropionate, or lindane plus estradiol dipropionate. An increase in neutrophils with a corresponding decrease in lymphocytes was also observed in rats treated with lindane or lindane plus estradiol dipropionate.
给去卵巢大鼠连续30天给予林丹（20毫克/千克·天），子宫、宫颈或阴道重量未出现显著变化。这些器官的组织学变化与去卵巢对照大鼠的变化相当。单独使用己烯雌酚二丙酸酯以及己烯雌酚二丙酸酯与林丹联合使用均导致这些器官重量显著增加。在显微镜下，这些器官看起来正常。与去卵巢对照大鼠相比，林丹使去卵巢大鼠子宫、宫颈和阴道的糖原含量显著增加，而在用己烯雌酚二丙酸酯或己烯雌酚二丙酸酯加林丹处理的去卵巢大鼠中，糖原增加了两到四倍。在用林丹、己烯雌酚二丙酸酯或林丹加己烯雌酚二丙酸酯处理的去卵巢大鼠中，总红细胞和血红蛋白显著增加。在用林丹或林丹加己烯雌酚二丙酸酯处理的大鼠中，还观察到中性粒细胞增加，淋巴细胞相应减少。
