Weiss H R, Levy P J, Kleinert H D, Murthy V S
Circ Shock. 1978;5(2):115-24.
A study was conducted on the effects of mild hemorrhage-induced hypovolemia and subsequent replacement with lactated Ringer's dextran or hemoglobin solution in 52 pentobarbital-anesthesized rats. Blood loss of 1.25% of body weight had no significant effect on the blood flow or relative tissue PO2 of the white matter of the cerebral cortex. Blood flow and relative tissue PO2 of the biceps brachii muscle were lowered during hypovolemia. Volume replacement with any of the three plasma substitutes had no effect on blood flow or relative tissue PO2 of cortical white matter. They all caused partial restoration of blood flow and relative tissue PO2 in the biceps brachii muscle. Full return in the muscle was not achieved, nor were there any significant differences between the treatment groups.
对52只戊巴比妥麻醉的大鼠进行了一项研究，观察轻度出血性低血容量以及随后用乳酸林格氏右旋糖酐或血红蛋白溶液进行补液的效果。失血1.25%体重对大脑皮质白质的血流或相对组织氧分压没有显著影响。低血容量期间肱二头肌的血流和相对组织氧分压降低。用三种血浆代用品中的任何一种进行容量替代对皮质白质的血流或相对组织氧分压没有影响。它们都使肱二头肌的血流和相对组织氧分压部分恢复。肌肉未完全恢复，各治疗组之间也没有显著差异。
