Weiss H R, Bailin J J, Levy P J
Circ Shock. 1978;5(4):365-74.
A study was conducted on the effects of mild hemorrhage-induced hypovolemia and subsequent fluid replacement with lactated Ringer's or dextran solution on the hearts of 61 pentobarbital anethetized open-chest New Zealand white rabbits. After a blood loss equivalent to 1.25% of body weight, blood flow in the subepicardial and subendocardial regions of the left ventricular free wall was unaffected, relative tissue PO2 fell, and small vessel blood content, a measure of open capillary density, increased. No regional differences were seen after one hour. With fluid replacement, small vessel blood content returned toward control; coronary blood flow and myocardial relative tissue PO2 were unaltered. These results are best explained by an increased myocardial metabolism and a loss of blood oxygenation in hypovolemia and a return of metabolism toward control with fluid replacement. The lack of regional effects indicated that the subendocardium was no more adversely affected than the subepicardium during the experimentally induced mild hypovolemia.
对61只戊巴比妥麻醉的开胸新西兰白兔进行了一项研究，观察轻度出血性低血容量及随后用乳酸林格氏液或右旋糖酐溶液补液对心脏的影响。失血相当于体重的1.25%后，左心室游离壁心外膜下和心内膜下区域的血流未受影响，相对组织氧分压下降，作为开放毛细血管密度指标的小血管血容量增加。1小时后未见区域差异。补液后，小血管血容量恢复至对照水平；冠状动脉血流量和心肌相对组织氧分压未改变。这些结果最好用低血容量时心肌代谢增加和血液氧合丧失以及补液后代谢恢复至对照水平来解释。缺乏区域效应表明，在实验诱导的轻度低血容量期间，心内膜下受到的不利影响并不比心外膜下更严重。
