Johnson B F, Black H R, Beckner R, Weiner B, Angeletti F
J Hypertens. 1983 Jun;1(1):103-7. doi: 10.1097/00004872-198306000-00017.
In 36 patients with normal renal function receiving hydrochlorothiazide and propranolol, lying diastolic blood pressure remained above 95 mmHg. In a double-blind trial, Step 3 therapy with 5-40 mg/day of minoxidil reduced blood pressure somewhat more effectively than 25-200 mg/day of hydralazine. The percentage of patients with lying diastolic blood pressure below 90 mmHg was 69 versus 35% at four weeks, and 55 versus 40% at 28 weeks. Transient falls in blood pressure within 4 h of any dose were greater with hydralazine which usually needed to be given in divided daily doses. Minoxidil caused tachycardia, and more adverse effects. Minoxidil is more effective, produces more consistent blood pressure control throughout the day, and may often be administered once daily.
在36例接受氢氯噻嗪和普萘洛尔治疗且肾功能正常的患者中，卧位舒张压仍高于95 mmHg。在一项双盲试验中，每日5 - 40毫克米诺地尔的第三步治疗比每日25 - 200毫克肼屈嗪能更有效地降低血压。卧位舒张压低于90 mmHg的患者百分比在四周时分别为69%和35%，在28周时分别为55%和40%。任何剂量下，4小时内血压的短暂下降在肼屈嗪组更明显，且肼屈嗪通常需要每日分剂量给药。米诺地尔会引起心动过速及更多不良反应。米诺地尔更有效，能在一整天内更稳定地控制血压，且通常每日给药一次。
